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March 24, 1923

Der chronische hereditäre hämolytische Ikterus. (Konstitutionelle Hypersplenie).

JAMA. 1923;80(12):871. doi:10.1001/jama.1923.02640390059034

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This is a discussion of every known phase of hemolytic icterus. Although the book does not enrich our knowledge of this condition by many new facts, it is of great value because it brings to our attention in a clear and compact form the author's methods of examination and deductions from his experience—he saw fifty cases in the course of four years—and it reviews the literature. The rôle assumed by hereditary influence is so important that to it the author applies the term dominant factor, on the basis of mendelian inheritance. Many cases may show some evidence of an early existence, such as a severe icterus neonatorum. Familial existence is well known. The rare occurrence of a high color index renders it possible that the condition under observation may belong to another group. Vital staining reveals that from 20 to 50 per cent, of the red cells are immature. The

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