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Article
May 5, 1923

THE INTRACARDIAC INJECTION OF EPINEPHRIN

JAMA. 1923;80(18):1314-1315. doi:10.1001/jama.1923.02640450034012
Abstract

The powerful pharmacologic effects of epinephrin have been a matter of interest to the medical profession since this active principle of the suprarenal gland was isolated by Abel, Takamine and Aldrich in the period from 1901 to 1903. Credit is given to Shäfer and Oliver for having first shown, in 1895, the power of the medullary substance of the suprarenal to raise the blood pressure. Recently, considerable publicity has been given to the power of the drug, when injected into the heart, to produce a response resulting in revivification when the heart has apparently ceased its action from certain causes. According to Bodon,1 medical officer of the United States legation in Budapest, who recently has reviewed the development of this use of epinephrin, the drug seems to have been first recommended for this purpose by Winter in 1905, although Latzko stated that he had attempted intracardiac injection on a

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