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More than forty years ago, the senior author of this book began to publish his observations and opinions concerning the structure of protoplasm, or sarcode, as he prefers to call it. He concluded then that protoplasm is always an organized substance and possesses a definite fundamental structure, which may undergo change with the specialization of function. The basis of this structure he conceived to be the spherule, which he regarded as a living entity, capable of assimilation, growth and division, that is, an elementary organism. The present book is a restatement of these views, based in part on the earlier, in part on later, observations. The authors describe and figure not only spherules but also granuloids, fibrilloids and vacuoloids, these being regarded as modifications of the fundamental structure. They assert that "elementary life" is not the life of the cell, but that of the elementary units. The simplest organisms, e.
La matière vivante. JAMA. 1925;84(4):308. doi:10.1001/jama.1925.02660300066038
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