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January 31, 1925

THE QUESTION OF THE EXISTENCE OF AMYLOID CASTS

Author Affiliations

PHILADELPHIA
From the laboratory of histopathology of the Philadelphia General Hospital.

JAMA. 1925;84(5):344-345. doi:10.1001/jama.1925.02660310018005

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Abstract

While many textbooks on medicine and clinical pathology contain the statement that "amyloid" or "waxy" casts are commonly found in the urine of patients with or without amyloid disease of the kidneys, the existence of such casts has been questioned. It is true that casts of a peculiar "waxy" appearance are sometimes encountered in microscopic urinalysis, and it is likewise true that the diagnosis of amyloid infiltration of the kidneys has later been confirmed by postmortem examinations. Since it is difficult for any one observer to collect a series of such data, it seemed a matter of some practical interest to study this problem by means of histologic sections of amyloid kidneys.

It may be recalled that, in the kidney, amyloid is usually present around the coats of the glomeruli, in the walls of the vessels in general, and in the lining of the basement membrane of some parts of

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