Since the publication of an earlier paper 1 on this subject, considerable additional work has been done, and many inquiries have been received, and it is believed that the observations presented here should be reported.
In the original paper, it was stated that cultures taken after exposure to chlorin remained sterile or developed only a few scattered colonies, and it was believed that "hour exposures appeared sufficient practically to sterilize the tonsillar, postnasal and pharyngeal surfaces."
Undoubtedly this conclusion was at least partially erroneous, and later investigations have shown that sterility of the mucous surfaces following the therapeutic administration of chlorin cannot be expected. The error was probably due to two conditions of the experiment. In the first place, normal volunteers were used for this work; and, as relatively few bacteria were obtained in the first culture, sterility in the second culture was obtained with relative ease. Again, a higher
VEDDER EB, SAWYER HP. THE TREATMENT OF CERTAIN RESPIRATORY DISEASES BY CHLORIN. JAMA. 1925;84(5):361–364. doi:10.1001/jama.1925.02660310035012
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