The recent attainment of Graham, Cole and Copher,1 visualizing the gallbladder by the simple and safe method of intravenous injection of the sodium salt of tetrabromphenolphthalein, has offered the opportunity for the investigations in the present report. The primary purpose of our studies is to determine whether or not the gallbladder is altered by a nonsurgical biliary drainage following the introduction of magnesium sulphate solution directly into the duodenum (Lyon-Meltzer technic). Heretofore all such observations on the gallbladder have been made on anesthetized animals and human beings during operation. Auster and Crohn,2 as a result of their experimental work on dogs, concluded that the gallbladder itself does not appear to participate actively in the biliary excretion. Differing with the latter, Sachs3 and Lesner4 have reported contractions of the gallbladder following stimulation with magnesium sulphate solution.
Friedenwald, Martindale and Kearney,5 in their series of experiments with thirty-four dogs, employing
SILVERMAN DN, MENVILLE LJ. OBSERVATIONS OF THE VISUALIZED GALLBLADDER BY GRAHAM METHOD: WITH REFERENCE TO THE EFFECT OF NONSURGICAL BILIARY DRAINAGE: PRELIMINARY REPORT. JAMA. 1925;84(6):416–418. doi:10.1001/jama.1925.02660320008003
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