The use of magnesium sulphate to assist in controlling intracranial tension was first introduced into this clinic a little more than two years ago. During this time, certain observations as to its effects and mode of administration have been recorded, and the conditions in which its use is beneficial will be noted. It was adopted by the neurosurgical service as a means of reducing intracranial pressure and volume, following my observation that infants showed a marked retraction of the fontanels after its use, because of the dehydration that it produces throughout the cerebral system.
At the time a method brought forward by Cushing and Foley1 of the intravenous injection of 35 per cent, sodium chlorid solution was in use, but since that time this method has been replaced in the majority of cases by the easier and more satisfactory administration of magnesium sulphate solution, either by rectum or by
FAY T. THE ADMINISTRATION OF HYPERTONIC SALT SOLUTIONS FOR THE RELIEF OF INTRACRANIAL PRESSURE. JAMA. 1923;80(20):1445–1448. doi:10.1001/jama.1923.02640470023010
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