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February 14, 1925


Author Affiliations

Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

JAMA. 1925;84(7):492-493. doi:10.1001/jama.1925.02660330012005

The test for hyperbilirubinemia as first set forth by Fouchet1 has recently been applied clinically in the diagnosis of cholecystitis without jaundice by Friedman and Straus,2 and later by Speik, Liljedahl and Falk.3 Friedman and Straus obtained positive reactions in 83 per cent, of a series of twenty-nine cases of cholecystic disease, and felt that the test was useful in distinguishing between gastric and duodenal ulcer, or carcinoma of the stomach and cholecystitis. In a series of forty patients with cholecystitis and stones, Speik, Liljedahl and Falk obtained a positive reaction in 67 per cent.; however, 42 per cent. of them showed the presence of excess bilirubin macroscopically. These investigators also found that many other conditions besides cholecystitis gave a positive reaction, among them being duodenal ulcer; hence, the differential diagnostic value of the test in certain conditions is impaired.2

In our investigation, the technic as