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February 21, 1925


JAMA. 1925;84(8):569-570. doi:10.1001/jama.1925.02660340007002

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Our purpose is to call attention to a relationship between certain cases of paroxysmal tachycardia and migraine. The conception arose from the observation of the frequent association of paroxysmal tachycardia with other manifestations of migraine. The idea was further enforced by the growing realization that migraine is a fundamental generalized constitutional disturbance, accompanied by definite physiologic and metabolic alterations in the tissues, and having as manifestations of these disturbances the various symptoms described in an attack, of which a sick headache is the most frequent.

We shall not consider at any length the various theories of etiology and the mechanism of production of an attack, but it should be pointed out that the condition is essentially a suboxidation—an inability of the tissues to utilize oxygen, in much the same manner that in diabetes the tissues fail to oxidize glucose. There is consequently an accumulation of acid products, as well as

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