Insulin treatment of diabetes, more than anything else, has demonstrated the clinical value of a knowledge of blood sugar levels. The increased frequency of hypoglycemia with its attendant dangers makes information concerning the concentration of glucose in the blood essential, and second to it is the importance of the determination of the degree of hyperglycemia. The urine often fails to indicate correctly the degree of hyperglycemia, since the percentage of sugar in the urine may remain the same through a wide variation of the concentration of the glucose in the blood. Particularly in cases of diabetic coma, blood sugar determinations are of high therapeutic value. The patient with an extremely high blood sugar receives more insulin than one with a moderate hyperglycemia. The effect of the first injection of insulin can be learned by a second blood analysis made an hour later, and this is the guide for further treatment.
Kiefer ED. A BEDSIDE METHOD FOR DETERMINING BLOOD SUGAR. JAMA. 1925;84(8):589–591. doi:10.1001/jama.1925.26620340001011
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