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Article
June 2, 1923

THE TREATMENT OF DIABETES MELLITUS WITH INSULIN

Author Affiliations

KANSAS CITY, KAN.
From the Department of Internal Medicine, University of Kansas School of Medicine.

JAMA. 1923;80(22):1597-1600. doi:10.1001/jama.1923.02640490017006
Abstract

The recent isolation by Banting and his co-workers of an active glycolytic, nontoxic, pancreatic extract opens up a new era in the treatment of diabetes mellitus. Ever since the classical experiment of Mering and Minkowsky proved the existence of pancreatic diabetes, frequent attempts at specific pancreatic therapy have been made. These attempts in the past have been uniformly unsuccessful and now possess little but historical interest.

The isolation of insulin, which is described as the active hormone of the islands of Langerhans, has excited unusual interest among both physiologists and clinicians. Allen1 has written an excellent summary of all articles published on this subject up to August, 1922, and enables one to trace step by step the various phases in the development of this important discovery.

A more recent article by Banting, Campbell and Fletcher2 describes the results obtained from the use of this preparation, in patients suffering

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