In 1920, Ravaut1 called attention to the usefulness of sodium thiosulphate in a number of conditions, including certain of the unfavorable sequelae of neo-arsphenamin administration. He gave three case reports of late reaction to neo-arsphenamin. The patients in all three cases had developed an arsenical dermatitis, and in addition one patient had symptoms and signs referable to the liver. Prompt recovery occurred in all three following the administration of sodium thiosulphate. Dennie and McBride2 report that twenty-five cases of arsphenamin dermatitis and ten cases of arsenic jaundice have been treated successfully. They also bring out the fact that sodium thiosulphate is curative in any form of poisoning due to arsenic, mercury, lead or bismuth. In the discussion following the report of Dennie and McBride, it seems evident that sodium thiosulphate has had an extensive clinical trial and that it has a wide usefulness. Other reports than those mentioned
McBRIDE RH. TREATMENT OF ARSPHENAMIN "ENCEPHALITIS" WITH SODIUM THIOSULPHATE: REPORT OF CASE. JAMA. 1925;84(10):729–730. doi:10.1001/jama.1925.02660360011004
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