The Meltzer-Lyon test for disease of the biliary tract has aroused a renewed interest in the motor mechanism of the gallbladder. Despite the large amount of research devoted to it, this phase of the physiology of the gallbladder remains quite obscure. I was convinced of this during some experimental studies on the excretion of foreign-body dyestuffs in the gastro-intestinal tract which I carried on in Professor Bickel's biologic laboratory in the University of Berlin.
It was found that the secretion in the bile of a subcutaneously injected dyestuff, specifically indigocarmin, was entirely ended in from eight to fifteen hours in a complete gallbladder fistula dog (i. e., one with the ductus choledochus ligated), while in a normal dog, not operated on, indigocarmin-colored bile remained in the gallbladder from four to five days. At the end of two weeks, the bile in the gallbladder was found uncolored by the dye. (The
WINKELSTEIN A. THE MOTOR MECHANISM OF THE GALLBLADDER. JAMA. 1923;80(24):1748–1750. doi:10.1001/jama.1923.02640510004002
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