[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
June 16, 1923


JAMA. 1923;80(24):1748-1750. doi:10.1001/jama.1923.02640510004002

The Meltzer-Lyon test for disease of the biliary tract has aroused a renewed interest in the motor mechanism of the gallbladder. Despite the large amount of research devoted to it, this phase of the physiology of the gallbladder remains quite obscure. I was convinced of this during some experimental studies on the excretion of foreign-body dyestuffs in the gastro-intestinal tract which I carried on in Professor Bickel's biologic laboratory in the University of Berlin.

It was found that the secretion in the bile of a subcutaneously injected dyestuff, specifically indigocarmin, was entirely ended in from eight to fifteen hours in a complete gallbladder fistula dog (i. e., one with the ductus choledochus ligated), while in a normal dog, not operated on, indigocarmin-colored bile remained in the gallbladder from four to five days. At the end of two weeks, the bile in the gallbladder was found uncolored by the dye. (The