Several roentgenologists have reported a dense shadow appearing on the roentgenograms of the chest of patients who have received roentgen-ray treatment over the thorax. The exact causation of this shadow has been in doubt. Carcinoma of the lung, pleural thickening, pleural effusion, and fibrosis due to the roentgen-ray treatment have been offered as possible explanations.
In 1922, Tyler and Blackman1 reported seven cases in which a dense shadow appeared on roentgenograms of the chest following heavy irradiation of the thorax for carcinoma of the breast, and suggested that the change might be due to a fibrous thickening of the pleura and lungs as a result of the roentgen-ray therapy. There were no necropsies in this group.
In similar cases reported by Drs. Pfahler, Groover and Case in the discussion of the article by Tyler and Blackman there were likewise no necropsies.
Dr. Pfahler was of the opinion that roentgen
ROSE CB. BREAST CARCINOMA TREATED SURGICALLY AND BY ROENTGEN RAYCLINICAL AND POSTMORTEM FINDINGS IN TWO CASES. JAMA. 1923;80(24):1750–1754. doi:10.1001/jama.1923.02640510006003
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