[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.173.48.53. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 14, 1925

THE TRANSFORMATION OF WHITE BLOOD CELLS: INTO CLASMATOCYTES (MACROPHAGES), EPITHELIOID CELLS, AND GIANT CELLS

JAMA. 1925;84(11):798-799. doi:10.1001/jama.1925.02660370008002

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

The great divergence of opinion as to the origin of the clasmatocytes, epithelioid cells, and giant cells of the Langhans type can be ascribed either to inadequate technic or to the possibility of a varied origin. The simple technic applied first by Mrs. Lewis to mammalian (man, dog, cat, mouse, guinea-pig) and avian (chicken) blood and by both of us to the blood of elasmobranchs, bony fishes, amphibia and reptiles enables one to prove beyond question that the white blood cells, in all the various forms studied, can give rise to clasmatocytes, epithelioid cells, and giant cells of the Langhans type. The method is so simple that any competent investigator can repeat our observations. Small drops of whole blood, taken under aseptic conditions from the heart or periphery, made into ordinary hanging drops and kept at suitable temperatures, contain, after a few days (from two to twenty-one), varying numbers of

First Page Preview View Large
First page PDF preview
First page PDF preview
×