One result of recent advances in our knowledge of the regulation of acid base equilibrium of the body has been a better understanding of the condition known as gastric tetany and of the various factors concerned with its production.
Beginning with the experimental work of McCann 1 and of MacCallum and his associates,2 many experimental and clinical studies3 have demonstrated that gastric tetany is accompanied by and associated with an alkalosis, as indicated by an increase in the blood bicarbonate and a decrease in the hydrogen ion concentration. There also occurs a lowered concentration of blood and urinary chlorids, an increase in the phosphates and sulphates, and a variable rise in the nonprotein nitrogen of the blood. In addition, under similar conditions blood changes in the same direction have been noted in animals and in patients exhibiting to a less degree some of the signs and symptoms observed
YOUMANS JB, GREENE IW. GASTRIC TETANY: REPORT OF A CASE TREATED WITH AMMONIUM CHLORID. JAMA. 1925;84(11):808–810. doi:10.1001/jama.1925.02660370018009
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