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June 30, 1923


JAMA. 1923;80(26):1940-1941. doi:10.1001/jama.1923.02640530052012

Amebic dysentery, one of the more important diseases caused by protozoa, has not yet been put into the category of disorders for which a treatment that is both satisfactory and rational has been established. Emetin has long been known to have a toxic action on cultural amebas, and there seems to be little doubt that the drug possesses a definite remedial potency in the endamebic infections in man. However, despite the benefits secured in human therapy with emetin, the management of amebic infections still leaves much to be desired. Sellards and Leiva1 of the Bureau of Science at Manila, for example, have lately called attention to the circumstance that few of the poorer Filipinos, even though they live in Manila, ever receive adequate and thorough treatment with emetin under satisfactory laboratory control. These investigators have given consideration to several plants belonging to the family Simarubaceae, which are very popular