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Article
July 14, 1923

THE PRECIPITIN REACTION OF THYROGLOBULIN: PRESENCE OF THYROGLOBULIN IN THE THYROID LYMPH OF GOITROUS DOGS

Author Affiliations

CHICAGO
From the John McCormick Institute for Infectious Diseases, and the Hull Physiological Laboratory of the University of Chicago.

JAMA. 1923;81(2):86-88. doi:10.1001/jama.1923.02650020004002
Abstract

As reported previously,1 human thyroglobulin, prepared according to Ostwald's method, contains a main, strictly specific antigenic element, and also apparently lesser antigens that in the rabbit may call forth precipitins for thyroglobulins of other species also, such as beef and swine. The latter thyroglobulins act as strictly specific precipitinogens, so far as the results at hand indicate. Since the precipitin reaction of thyroglobulin seems to be a rather sensitive test, we have applied it in an effort to throw light on the question of how the active secretion of the thyroid gland is given off. For this purpose, we are studying the lymph and blood of the thyroid for the presence of thyroglobulin, and this report deals with the thyroid lymph of goitrous dogs.

PRECIPITIN TEST FOR DOG THYROGLOBULIN  Dog thyroglobulin was prepared in the same way as described,1 and rabbits were immunized with it by intravenous injections. In

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