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July 14, 1923


JAMA. 1923;81(2):138-139. doi:10.1001/jama.1923.02650020056014

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Newspapers have carried extended notices of the Dreyer so-called "defatted" tuberculosis vaccine. Many inquiries have been received, indicating that, with ever-watchful hopefulness, physicians and patients are still alert for news of any promising announcement of a successful specific treatment for tuberculosis. The complete report of the researches conducted by Professor Dreyer, of the department of pathology in Oxford University, appears in the British Journal of Experimental Pathology for June, and an extensive abstract is available in the British Medical Journal for June 23, 1923, both just received.

It has long been known that the tubercle bacillus has a coating of waxy or fatty material, generally called lipoidal substances. Experiments conducted in this country and elsewhere seem to indicate that the virulence of organisms rests, to some extent, on the concentration of such lipoids in their coats or capsules. As Dreyer says, "there was an a priori probability that the failure

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