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July 14, 1923

The Constitutional Factors in Dementia Praecox, with Particular Attention to the Circulatory System and to Some of the Endocrine Glands.

JAMA. 1923;81(2):158. doi:10.1001/jama.1923.02650020076032

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In this small monograph are presented the summary of the findings in 601 necropsies in cases of hebephrenic and catatonic dementia praecox at St. Elizabeth's Hospital, Washington, D. C., and detailed clinical and necropsy reports on twenty-two additional cases. Paranoid dementia praecox is separated off as a special group with peculiarities of its own which will be reported later. The striking findings are: the very large proportion of cases (75.5 per cent.) that presented a small aplastic heart and blood vessel system, which incomplete development appears to extend even to the capillary system. This proportion is greatly in excess of all other forms of mental disease and is approached only by the cases of general paralysis; marked lymphatic hyperplasia; and histopathologic changes especially in the thyroid, suprarenals and gonads. These findings are offered, not as an explanation of dementia praecox, but rather as a soil on which for some reason

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