Intracardiac injection of heart stimulants in acute cardiac failure had been tried many times without promising results until Dennis Crile1 of Chicago reported the use of massive doses of epinephrin chlorid. He introduced this both by direct puncture into the ventricle and by the intravenous route, showing beneficial results in all five cases reported, with recovery in two of them. Bodon2 has since reported ninety cases from the literature with permanent results in twentyfour, including one case of his own. In this series, a variety of stimulants were used, with no special emphasis on any single one. In Bodon's case, a patient with syphilitic coronary arteritis with acute cardiac failure, he used 1 c.c. of a 1: 1,000 epinephrin chlorid solution as a last resort after cessation of heart and respiration. A few seconds after this had been given by direct puncture into the ventricle, the heart began
CHAMPLIN PB. RESUSCITATION BY INTRACARDIAC INJECTION OF EPINEPHRIN CHLORID. JAMA. 1923;81(3):202–203. doi:10.1001/jama.1923.02650030026010
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