In our last article in The Journal, we1 stated that we were making clinical use of sodium tetraiodophenolphthalein for cholecystography for comparison with an equal number of patients who were given injections of sodium tetrabromphenolphthalein. Since the publication of this article, Whitaker and Milliken2 have published their experimental results from a comparison of these two substances.
Sodium tetraiodophenolphthalein was the first substance that we3 used in an attempt to visualize the gallbladder. The first sample of sodium tetraiodophenolphthalein that we used had different physical characteristics from those of the samples obtained later. The first sample of sodium tetraiodophenolphthalein proved to be more toxic than sodium tetrabromphenolphthalein. The purified product of sodium tetraiodophenolphthalein, which we are now using, is no more toxic in equal doses than sodium tetrabromphenolphthalein. Equally good cholecystograms can be obtained with tetraiodophenolphthalein in much smaller doses than with tetrabromphenolphthalein. This is possible because of
GRAHAM EA, COLE WH, COPHER GH. CHOLECYSTOGRAPHY: THE USE OF SODIUM TETRAIODOPHENOLPHTHALEIN. JAMA. 1925;84(16):1175–1177. doi:10.1001/jama.1925.02660420013004
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