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April 25, 1925

ROSEOLA OF THE CONJUNCTIVA: A SUBACUTE EXANTHEMATOUS CONJUNCTIVITIS, PECULIAR TO SECONDARY SYPHILIS; REPORT OF THREE CASES

JAMA. 1925;84(17):1256-1258. doi:10.1001/jama.1925.02660430014005

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Abstract

There is a type of conjunctivitis seen in exanthematous diseases such as measles, smallpox, typhus and scarlet fever, usually preceding the skin manifestation. The pathologic changes in this form of conjunctivitis are analogous to those in the eruption of the skin. It is in reality a form of hyperemic conjunctivitis with red blood cell diapedesis, wherein it varies, I believe, from the ordinary forms of conjunctivitis, in which the conjunctiva can be blanched by pressure or instillation of epinephrin. The conjunctivitis of the exanthematous type is characterized by its suddenness of onset, lack of discharge, some photophobia (not found in usual forms of conjunctivitis) and little or no lacrimation.

The symptoms develop in a subacute or chronic manner, with an itching and sometimes burning sensation of the eyes. This disease picture is so common in early measles that further description is unnecessary.

I have recently observed several cases of exanthematous

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