McClure and Aldrich 1 found that the elevation produced by intradermal injection of 0.2 c.c. of an 0.8 per cent, aqueous solution of sodium chlorid became impalpable much more quickly in a group of children having edema than in a group of control cases. While in the individual edematous patient the disappearance of the elevation was less rapid in skin areas in which pitting by pressure was not demonstrable than in areas in which palpable edema was present, yet even in the nonpitting areas the disappearance was considerably more rapid than in the control cases. In a later paper 2 they report the results of use of this test in sixteen cases in children characterized by generalized edema with albumin, casts and, in some cases, red blood cells in the urine, with absence of nitrogen retention in the blood and without evidence of cardiovascular disease. They found that in a
HARRISON J. INTRADERMAL SALT SOLUTION TEST IN LOBAR PNEUMONIA IN CHILDREN. JAMA. 1925;84(17):1258–1259. doi:10.1001/jama.1925.02660430016006
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