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April 25, 1925


Author Affiliations


JAMA. 1925;84(17):1261-1262. doi:10.1001/jama.1925.02660430019008

Because of the many inquiries regarding the method of administration of magnesium sulphate that I1 have employed in cases of increased intracranial pressure, an outline of treatment, based on four years of experience and observation at the University Hospital, is offered in the management of such cases.

  1. Magnesium sulphate, if properly administered, will definitely reduce intracranial pressure within a few hours.

  2. Reduction of pressure may be maintained by its repeated use over a period of weeks.

  3. Acute pressure phases seen in traumatic head injuries can be adequately combated so that decompression for pressure has been found unnecessary in this hospital for the last three years.

  4. Magnesium sulphate is given as a routine in all intracranial injuries, with the exceptions noted below.

  5. Results have shown that the reduction of brain volume is greater and more satisfactory than the limited possibility offered by subtemporal decompression for pressure, and obviates the necessity