It is estimated that fully 20 per cent, of all pregnancies end in spontaneous abortion. This economic loss is accompanied by considerable physical suffering, and brings in its wake much mental distress. Furthermore, spontaneous abortion frequently strikes the homes of those who greatly desire children and are well able to provide them with unusual advantages. All these factors serve to emphasize the need of more work in this field.
Introductory to a consideration of the causes of "spontaneous" interruption of gestation, it would appear helpful to estimate the relative etiologic importance of physiologic disturbances as contrasted with pathologic processes. Many spontaneous abortions occur in women who fail to give evidence of pelvic lesions; but, despite this, I have long inclined to the belief that careful study should reveal pathologic conditions to be the more important etiologic factor. This belief is strengthened by the observations of Mall,1 who reported 50 per
CURTIS AH. SPONTANEOUS RECURRENT ABORTION: AN INQUIRY INTO THE CAUSES AND PREVENTIVE TREATMENT. JAMA. 1925;84(17):1262–1264. doi:10.1001/jama.1925.02660430020009
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