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Article
April 25, 1925

ALKALIS AND GASTRIC SECRETION

JAMA. 1925;84(17):1275-1276. doi:10.1001/jama.1925.02660430033017
Abstract

There are few drugs that find a more widespread use, not only in the prescriptions of physicians, but also through the dictates of lay tradition, than does the alkali sodium bicarbonate. It is popularly employed in the household without medical direction for the relief of the vague symptoms comprehended in the ill defined term indigestion; the bicarbonate is made to function as a so-called antacid, particularly when a diagnosis of hyperacidity is ventured; and the alkali is also occasionally ingested in the belief that somehow it will function as a digestant by promoting gastric secretion. In addition to these familiar everyday employments of sodium bicarbonate for alimentary responses, either as such or in the guise of one of the various "mineral waters" of which it forms the most potent ingredient, the drug is administered therapeutically to combat acidosis of a general or systemic type.

It is surprising that there should

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