During the last three years it has been shown that the vesicles of herpes febrilis or herpes simplex contain a virus that can be readily transferred to the cornea of the rabbit, where it causes a keratitis and a purulent conjunctivitis. The disease can then be passed from rabbit's cornea to rabbit's cornea indefinitely. The rabbit is also susceptible to the virus inoculated directly into the brain, testicle, ovary, suprarenal and certain other organs, though subcutaneous inoculations have yielded uniformly negative results.
Lipschütz1 inoculated the virus of herpes genitalis from vesicles on the female genitalia on the scarified skin of the thigh of the patient, and observed the appearance of a group of herpetic vesicles at the site of inoculation. Levaditi2 produced vesicles in the skin of rabbits at the site of inoculation, using a herpetic virus that had been passed from rabbit to rabbit many times.
TEAGUE O, GOODPASTURE EW. EXPERIMENTAL HERPES ZOSTER: PRELIMINARY REPORT. JAMA. 1923;81(5):377–378. doi:10.1001/jama.1923.02650050031010
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