In 1915, Lambert and Patterson1 said:
The therapeutics of mercuric chlorid poisoning up to the present have been quite unsatisfactory. The patients have regularly developed anuria on or about the fourth day after taking the poison, and progressed to subsequent death from lesions of the liver and colon, with or without the reestablishment of urinary secretion.
This statement represents fairly well the pessimism prevailing at that time with regard to the prognosis in clinical poisoning by mercuric chlorid. Nevertheless, these authors were able to report recovery in all of ten cases which were treated by a method in which measures designed to hasten elimination of the metal were especially stressed. Since the appearance of the paper by Lambert and Patterson, other observers have seen similar good results occur in mercuric chlorid poisoning when this eliminative treatment has been employed. The rigid application of the Lambert-Patterson treatment subjects the patient
HASKELL CC, CARDER JR, COFFINDAFFER RS. THE VALUE OF FORCING FLUID IN THE TREATMENT OF MERCURIC CHLORID POISONING. JAMA. 1923;81(6):448–450. doi:10.1001/jama.1923.02650060018004
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