Quinin has been used in heart treatment for a long time, certainly for more than sixty years. I must confess that I have not had time in these last years to look up the history of quinin as a heart drug, but I have heard that Ludwig Traube, the most outstanding man in experimental work in connection with clinical findings, added quinin to digitalis to prevent or relieve the disagreeable action of this drug on the stomach. I do not know whether this is true or not, but it is so related. Among the older generation of clinicians there was a good number, and I knew some of them, who nearly always gave digitalis in combination with quinin. On being asked why they did it, they could not give me an exact reason for it; but they found that digitalis was better supported with quinin and that they could give
WENCKEBACH KF. CINCHONA DERIVATIVES IN THE TREATMENT OF HEART DISORDERS. JAMA. 1923;81(6):472–474. doi:10.1001/jama.1923.02650060042012
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