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Article
May 9, 1925

LOCALIZED GANGRENE FOLLOWING THE HYPODERMIC ADMINISTRATION OF CALCIUM CHLORID

Author Affiliations

Professor of Clinical Surgery, Washington University School of Medicine ST. LOUIS
From the surgical service of the Jewish Hospital of St. Louis.

JAMA. 1925;84(19):1413-1414. doi:10.1001/jama.1925.02660450021012
Abstract

Symptoms of obstructive jaundice invariably create a serious problem for the surgeon, if an operation is to be performed to relieve either the jaundice or some other intercurrent symptom. The physical resistance of this group of patients is lowered; but this, in itself, does not constitute the major surgical problem. Hemorrhage, frequently not responsive to any type of treatment, and ending in death, is the factor that renders surgical judgment difficult in every instance of obstructive jaundice. In the present state of our knowledge, it is not easy to say with positive assurance what agency is directly responsible for this tendency to bleed. As surgeons we have become accustomed to associate a prolonged clotting time with obstructive jaundice; however, we are not warranted even in taking this seemingly well established position. We would be on safer ground if we regarded every jaundiced patient as

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