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Article
May 9, 1925

HISTOPATHOLOGY OF AGRANULOCYTIC ANGINA

Author Affiliations

Oak Park, Ill.
From the West Suburban Hospital.

JAMA. 1925;84(19):1415-1416. doi:10.1001/jama.1925.26620450001013
Abstract

Microscopic slides from a case of this rare disease promise interesting and unusual findings, in addition to suggesting the possible answers to several difficult questions. What are the inflammatory changes when the army of defense, the polymorphonuclears, is completely destroyed? What is the significance of the clinical symptoms? Where are the primary lesions located, and what is the cause of this disease?

As was pointed out in the clinical report of this case by Dr. J. H. Skiles,1 only the abdominal cavity was examined. The necropsy was performed ten hours after death. I fixed the tissues in Bouin's fluid and made paraffin sections from the liver, spleen, kidneys, stomach, ovary and suprarenal glands. Hematoxylin-eosin, Gram-Weigert's, Gram's (original) methylene blue and Wright's stains were used.

The liver showed no marked changes, its general structure being well preserved. In some places, diffuse perivascular lymphocytic infiltration was present, while the capillaries and

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