Proper schedules of dietary regulation, as well as the rational use of insulin in the management of diabetes, postulate an understanding, in the case of each patient, of the limits of his "tolerance" to foods of various sorts. In the case of the newly discovered pancreatic hormone the fact that it is, so to speak, somewhat evanescent in its action calls for not only a satisfactory determination of dosage but also a proper routine with respect to the time of its administration. As one student of the problem of therapy in diabetes has summarized the situation, it is obviously to be desired that the doses of insulin be as small and the administrations as infrequent as possible. Moreover, he adds, with a diet adequate for maintenance and reasonable activity, the blood sugar concentration throughout the day must be held within normal limits. To accomplish this requires, first, an appreciation of
RECENT CONSIDERATIONS IN THE MANAGEMENT OF DIABETES. JAMA. 1925;84(19):1424–1425. doi:10.1001/jama.1925.02660450032019
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