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May 9, 1925

"PHENOLTETRACHLORPHTHALEIN LIVER FUNCTION TEST"

JAMA. 1925;84(19):1444. doi:10.1001/jama.1925.02660450052035

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Abstract

To the Editor:  —In a paper by Maurer and Gatewood in The Journal, March 28, the following statement appears: "We know that the fate of colloid dyes in the organism is entirely different from that of diffusible dyes." Can you give me any references on this subject?

Ernest W. Willetts, M.D., Pittsburgh.  Note.—The letter of Dr. Willetts was referred to Dr. Gatewood, who replies: The statement referred to is quoted from the work of Delprat and Evans, who have gone into this problem at great length. In Evans' earlier papers he regarded the removal of dyes as a definite vital staining process, but in his later work changed his position and brought forward proof that the dyes are phagocytized. The most important reference is probably that of Evans, H. M.: Anatomical Record98, 1904. There are also two important papers by Nathan in the Journal de l'anatomie et de

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