Although the cause and nature of hypertension are still unknown, certain groups of cases have been differentiated from the general mass of those with high blood pressure, and certain clinical associations have been established. Thus, it is generally accepted that patients with glomerulonephritis and hypertension, or with the vascular crises of lead, eclampsia or tabes, must be sharply distinguished from those with so-called essential hypertension. Among those belonging to the latter category, certain subgroups have been described: hypertension associated with myxedema,1 and hypertension associated with tumors of the suprarenal cortex.2
There is another syndrome, in which hypertension is one of the presenting signs, but in which there is a concomitant group of symptoms which serve to separate it sharply from the ordinary picture of hypertension, and which warrant its classification as a distinct disease entity. The signs and symptoms characteristic of this syndrome may briefly be enumerated as
BOAS EP, SHAPIRO S. DIASTOLIC HYPERTENSION WITH INCREASED BASAL METABOLIC RATE. JAMA. 1925;84(21):1558–1560. doi:10.1001/jama.1925.02660470020004
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