A great deal of discussion concerning the value of fractional gastric analysis has taken place since Gorham 1 pointed out that the publications of many physiologists tended to show variations in the acidity of different parts of the stomach, and that such variations could be conclusively demonstrated if a test meal was given, the stomach rapidly emptied, and the acid content of successive specimens determined. His experiments have been confirmed by Wheelon,2 who carried out similar experiments on normal subjects; by Kopeloff,3 who not only carried out experiments similar to those of Gorham, but also determined the acidity of specimens aspirated simultaneously through three tubes in different parts of the stomach; by White;4 by Lockwood and Jacobson, 5 and by Friedenwald, Gantt and Morrison.6
The results of these studies, with the exception of a few determinations discussed but not presented in detail by Lockwood and Jacobson,
HUBBARD RS, MUNFORD SA. VARIATIONS IN THE ACIDITY OF DIFFERENT PARTS OF THE GASTRIC RESIDUUM. JAMA. 1925;84(21):1565–1566. doi:10.1001/jama.1925.02660470027007
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