The fact that double ovariectomy abolishes the cyclic changes which normally occur in the genital tract of female mammals demonstrates that these changes are due to some influence from the ovaries. That this influence is hormonal in nature is indicated by the maintenance of cyclic changes by autotransplantation of the ovaries to other sites in the body.1 Many attempts have been made to localize the seat of production of an internal secretion in definite ovarian structures. The follicles, the corpora lutea2 developing in them after ovulation, and the interstitial tissue 3 have all been cited as possible sources, and many different ovarian preparations have been used clinically in the belief that therapeutic effects were being secured from accompanying hormones.
But there appears to be no conclusive evidence of either a definite localization of the hypothetic hormone or of the specific effect claimed for the commercial ovarian extracts in
ALLEN E, DOISY EA. AN OVARIAN HORMONE: PRELIMINARY REPORT ON ITS LOCALIZATION, EXTRACTION AND PARTIAL PURIFICATION, AND ACTION IN TEST ANIMALS. JAMA. 1923;81(10):819–821. doi:10.1001/jama.1923.02650100027012
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