The 1923 edition of New and Nonofficial Remedies, published by the American Medical Association, states that ovarian therapy is still on trial. This might well be expected in view of the paucity of knowledge about ovarian function. For some time it has been recognized that the ovaries probably produce internal secretions or liberate hormones of some sort that are necessary for the proper activities of the uterus; and it has further been suspected that these chemical products may have obscure effects on metabolism and the nervous system. Persons who have not given detailed attention to ovarian problems often fail to realize that the organs engaged in ovulation are notably complex in structure. The discharge of the ovum leads to the formation of the corpus luteum, which has of late come into prominence in the physiology of the sexual cycle. There is experimental evidence that so long as the corpora lutea
THE CORPUS LUTEUM AND THE UTERUS. JAMA. 1923;81(10):832–833. doi:10.1001/jama.1923.02650100040020
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