These studies were conceived with the idea that possibly the use of some of the more recently used chemotherapeutic compounds might have an effect on the virus of rabies and also divulge a lead to the successful treatment of other diseases, the etiology of which is classified as an ultramicroscopic virus.
It should be borne in mind that the marked neurotrophic affinity of rabies virus and the inability of the majority of chemical compounds to penetrate to the
central nervous system in therapeutic quantity following administration by any of the known practical methods, especially intravenously, are two of the outstanding obstacles in the path of successful treatment. Also such compounds possessing somewhat marked germicidal properties, when injected intravenously in diseases of bacterial and protozoan etiology, are so markedly organotrophic when injected directly into the spinal canal, even in subtherapeutic doses, as to make their use by this route impracticable.
HARKINS MJ. CHEMOTHERAPEUTIC STUDIES IN RABIES. JAMA. 1925;84(24):1797–1798. doi:10.1001/jama.1925.02660500005003
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