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June 13, 1925


JAMA. 1925;84(24):1798-1800. doi:10.1001/jama.1925.02660500006005

The high rate of incidence of thyroid enlargement during pregnancy is well known. The frequency with which changed psychologic reactions, such as increased irritability, nervousness and emotionalism, occur is also a matter of common knowledge. Little significance is ordinarily attached to either.

Not infrequently, however, associated with thyroid enlargement and increased nervous sensitivity we hear complaints of troublesome insomnia, headache and palpitation, and we find tachycardia and an increase in blood pressure. It is either the tachycardia or hypertension, or both, that directs our attention to the possibility that the complaints may not be simply the result of nervous instability.

During the last four years in the medical clinic of the Chicago Lying-In Hospital we have observed a considerable number of women who presented such symptoms and physical findings. At first we attributed the whole picture to the increased nervousness of the pregnant woman, but we noticed that only a