It is a matter of general statement that infestation with Endameba coli is harmless. Many authorities hold further that it is not eradicable. In the knowledge that E. coli lives chiefly or entirely in the intestinal contents, it is assumed that it cannot damage the intestinal mucosa. The chief departure from this teaching is found in the effort of Kofoid to establish a separate species of E. coli named Councilmania lafleuri, which, he believes, is pathogenic. As to the validity of this species, we are not here concerned. To forestall criticism, however, on this point, we have recognized in a separate series those of our cases in which E. coli of the Councilmania type was harbored.
One of us 1 has previously taken the position that E. coli, together with the other intestinal protozoa, may be potentially pathogenic. This capacity to damage the host has been stated to be possible:
HALL JH, REED AC. ENDAMEBA COLI: A CLINICAL STUDY. JAMA. 1925;84(25):1914–1915. doi:10.1001/jama.1925.02660510030010
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