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July 4, 1925


JAMA. 1925;85(1):35. doi:10.1001/jama.1925.26710010001013a

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White considers the predisposition to urticaria hereditary. But in the study of herpes, no one besides observing a marked predisposition in certain persons seems to have mentioned a possible hereditary tendency. The accompanying illustration shows the occurrence of herpes facialis and urticaria among four generations of one family. Squares represent males, circles represent females; those shaded with parallel lines represent individuals having herpes, and those shaded with cross-lines represent individuals who have both herpes and urticaria.

If the tendencies to herpes and urticaria in this family are inherited, they have indications of being mendelian recessive characters. The great-grandparents may have been heterozygous in this regard; for although they did not have either herpes or urticaria, they may have been able to transmit the tendency to their offspring, as four of their thirteen children had herpes. The diagram also shows, in accordance with the mendelian theory, that if one parent is

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