The time honored and generally accepted view that pepsin and hydrochloric acid are necessary for the digestion of connective tissue has again been questioned, this time by Buckstein.1 He sewed the tip of a duodenal tube to the rubber tubing by means of catgut or kangaroo tendon, allowed it to pass on to the jejunum, and demonstrated that after a lapse of some time the tip became detached from the rubber tube. From this experiment he drew the conclusion that the catgut or kangaroo tendon was digested in the small intestine. A previous experiment with similar results on a patient with achylia gastrica2 fortified him in the correctness of his conclusions.
The publication of the results of these experiments under the challenging title of "The Fallacy of the Sahli Desmoid Reaction" drew fire from the pen of the originator of this well known test. In a letter to
SAGAL Z. THE DIGESTION OF CONNECTIVE TISSUE. JAMA. 1925;85(2):92–94. doi:10.1001/jama.1925.02670020012007
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