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I have observed thirty-one cases treated with unconcentrated scarlet fever serum by the Dochez method. In the thirty-one patients treated, twenty-one developed serum disease. These reactions ranged in severity from slight urticarial eruptions to a generalized edema, and the temperatures as high as 105 F. Six of the cases showed anaphylaxis in the first hour. Eighteen cases either occurred or recurred from the second to the seventh day. Nine patients had an elevation of temperature from 100 to 105 F.
The following are typical of two cf the more severe cases of serum disease:
—A girl, aged 5 years, was exposed to scarlet fever; she was given 3 c.c. of unconcentrated scarlet fever serum. Three days later, she developed symptoms of marked generalized edema and urticaria. Accompanying these were nausea, aching pains in the extremities and a temperature ranging from 100 to 104.2 F. These symptoms subsided gradually
GRAHAM RH. DOCHEZ SCARLET FEVER ANTITOXIN IN THIRTY-ONE CASES. JAMA. 1925;85(2):95–96. doi:10.1001/jama.1925.02670020015009
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