Some time ago, Dr. Emil Mayer, chairman of the Committee for the Study of Toxic Effects of Local Anesthetics, called my attention to a paper by Karl Mayer 1 and one by Hofvendahl,2 with a request that a report on their results be prepared for the committee. Shortly after my report was submitted to Dr. Mayer, the chairman of the committee, a paper was published by Frank, Strauss and Smiley 3 in which they stated that they were unable to observe any antagonistic action of calcium toward cocain, such as Karl Mayer had reported. They offered no explanation of the discrepancy between their results and those of Mayer, and it seems desirable, therefore, to publish the result of my investigation and to explain the discrepancy mentioned.
Karl Mayer's work is fundamentally faulty, so far as one can judge from his paper, in that he did not determine the fatal
WEISS S. A STUDY OF THE ACTION OF CALCIUM IN EXPERIMENTAL COCAIN POISONING. JAMA. 1923;81(15):1282–1283. doi:10.1001/jama.1923.02650150036010
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