The determination of the quantity of albumin in the cerebrospinal fluid may often afford information of distinct value in separating normal from pathologic fluids.
Several methods have been proposed for the purpose. Bybee and Lorenz have employed the Brandenburger method for urinalysis, while Mestrezat has made use of a colorimetric method. Nissl has utilized the precipitation of the albumin by Esbach's reagent, measuring the precipitate by centrifugating. An opalescent reaction has been described, in which to a known quantity of cerebrospinal fluid nitric acid is added drop by drop. This mixture is carefully shaken until opalescence remains constant. The degree of opalescence is then compared to a standard previously graded, and indicating that a certain degree of opalescence corresponds to a definite amount of albumin per liter.
None of these methods are as simple, we believe, as that proposed by Sicard and Canteloube,1 and it is with the purpose
Regan JC. A SIMPLE METHOD FOR MEASURING THE QUANTITY OF ALBUMIN IN THE CEREBROSPINAL FLUID BY THE SICARD-CANTELOUBE RACHIDIAN ALBUMINOMETER. JAMA. 1923;81(15):1285. doi:10.1001/jama.1923.26510150002012a
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