In January, 1923, Dr. W. J. MacDonald,1 a clinician of St. Catherines, Ontario, conceived the view that the liver secretes a substance that plays an important part in the regulation of blood uric acid, and that if such a substance could be recovered, it might be of service in the control of cancer. This conception was based on the fact, to which he himself refers, that Killian and Kast had shown a definite increase of uric acid in the blood of 80 per cent, of cases of internal cancer, and that Mann and Magath had found the uric acid in the blood mounting steadily until death in dogs from which the liver had been removed. During 1924, Dr. MacDonald prepared many extracts of liver and tested their toxicity on dogs and cats. Finally, in December, he noticed that the blood pressure fell steadily in two cases of carcinoma in
LOWERING THE BLOOD PRESSURE WITH LIVER EXTRACT. JAMA. 1925;85(3):194–195. doi:10.1001/jama.1925.02670030036011
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