Acne vulgaris can hardly be considered a disease of great importance in the majority of cases. At times, however, it is severe enough to present a problem that is worthy of serious attention, affecting not only the peace of mind but even the earning capacity of its victim. In the treatment of this rather stubborn disease, both the roentgen ray and vaccines have been, and still are, rather widely used. With the object of comparing the therapeutic value of these two remedies, this paper has been written.
Without discussing the pathology of acne at length, it should be recalled that the essential process in this disease is a functional overactivity of the sebaceous glands, combined with a follicular hyperkeratosis. To this is frequently added more or less pustulation, and, at times, deep seated granulomatous infiltration. The therapeutic indication is to inhibit the overactivity of cells of the sebaceous glands and
FOX H. THE ROENTGEN RAY VERSUS VACCINES IN THE TREATMENT OF ACNE. JAMA. 1923;81(17):1417–1423. doi:10.1001/jama.1923.02650170015006
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