Tumors of the hypophysis, because of their uncertainty of origin and the clinical phenomena associated with them, form one of the most interesting of all groups of neoplasms.1
According to the portion of the gland involved, the pituitary tumors vary in their pathology and clinical course. The anterior lobe is usually involved in the malignant and in the adenomatous types. Many cases are simple hyperplasias. Heteroplastic tumors are always associated with hypopituitarism, and manifest themselves by compression on the gland. The simple hyperplasias may or may not be associated with acromegaly, gigantism or obesity. These may go on to malignant change or may spontaneously regress. No case of acromegaly, however, has been associated with a heteroplastic tumor except one in which a glandular hyperplasia and a cerebellar cyst were coexistent.2 These tumors often interfere with neighboring structures, and give rise to pressure on the optic chiasm. The visual
Kaplan II. ROENTGEN-RAY THERAPY IN PITUITARY TUMOR. JAMA. 1925;85(4):268–269. doi:10.1001/jama.1925.26710040004009d
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