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October 27, 1923


JAMA. 1923;81(17):1442-1443. doi:10.1001/jama.1923.02650170040018

Adequate knowledge of the factors that enter into the formation of urine and determine the conditions under which it is excreted by the kidneys must obviously be of great importance in many considerations of the functions of the living organism. What is it that promotes, what retards, the renal activities? Strange as it may seem in this era of experimental physiology, the answers to these questions have been under debate for nearly half a century. Consequently, teachers and textbook writers have become accustomed to present the problem of kidney function with unusual deliberation and—what is always unsatisfactory— without marked conviction as to the proper conclusion to be drawn. Students have thus been taught for years to rehearse the competing theories respecting the secretion of urine.

Has not the time arrived to recognize that a satisfactory answer to some of the aspects of the subject is now at hand? The fact